Basophils

Basophils, although less understood and discussed compared to other white blood cells, plays a crucial role in immune responses and inflammatory reactions. Exploring the role of basophils in pregnancy sheds light on their significant​ in maternal health and provides valuable insights into immune regulation during this unique time.

Basophil Testing

The absolute basophil count tells you the total count of basophils in the sample. The basophil percentage tells you what percentage of white blood cell count is made up of basophils. It is found in the complete blood count (CBC) with differential panel.

The percentage is arguably more accurate that absolute, as it takes into account the total production of white blood cells and compares the amount of basophils to this total. 

Basophils compose 0.5% to 1% of all leukocytes in the human body. They are found in all inflammatory reactions, especially allergic reactions, and also play a role in both internal and external parasitic infections. During an inflammatory response, basophils produce histamines and heparin. Histamines enlarge blood vessels in affected areas. Heparin prevents clotting.

​Basophils are primarily associated with diseases that cause tissue inflammation.

Basophils in Pregnancy

​During pregnancy basophil levels slightly decrease and return to normal 4-6 weeks postpartum. This decrease should not be evident in the blood work. Although their role in pregnancy is still being elucidated, basophils are believed to contribute to the regulation of tissue repair processes. 

High Basophils in Pregnancy

Limited Research.

Most Common Causes of High Basophils in Pregnancy

• Acute Allergic Reaction
• Parasite Infections
• Acute Viral Infection
• Acute Tissue Damage/Physical Trauma
• Generalized Allergies/Asthma
• Systemic Inflammation
• Autoimmune Thyroid Disease
• Autoimmune Disease
• Pesticide Exposure
• Environmental Chemical Exposure
• Heavy Metal Exposure

Low Basophils in Pregnancy

Limited Research
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Due to measurement techniques, analysis at low levels is difficult, due to the small presence of basophils in samples.

Most Common Causes of Low Basophils in Pregnancy

• Chronic Inflammation
• Chronic Infections
• Autoimmune Disease
• Hypothyroidism
• Stress
• Adrenal Hyperfunction
• Low Progesterone
• Nutritional Deficiencies (Magnesium)

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Medical Disclaimer:
This content is for educational purposes only and is intended for licensed medical professionals. It is based on current research, subject to change, and not intended to diagnose, treat, or prevent any medical condition. This information does not replace consultation with a qualified healthcare provider. Seek professional medical evaluation and treatment from a licensed provider. Use of this information is at your own risk.

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