RDW TestingRDW measures the variability in red blood cell size. The lab analysis of the size is not based on the actual width of the cell but the width of the curve of the red blood cell. RDW-SD and RDW-CV are often analyzed as part of the red blood cell blood analysis:
We will talk about RDW-CV in this section. RDW-CV = (Standard Deviation of MCV / MCV) × 100 This gives us a percentage value. RDW in PregnancyThere is a rise in RDW in the last four to six weeks of pregnancy, with no known etiology. Early increases in RDW are associated with pregnancy loss, so it is theorized that this may be a biological change close to parturition. The increase in RDW is primarily driven by an increased release of nucleated red blood cells, as well as younger reticulocytes. Some variability is normal, as it represents a healthy balance between young reticulocytes and older mature red blood cells in circulation. A release of nucleated red blood cells (nRBC) into circulation can cause larger variation in RDW, as will a decrease in red blood cell production. High RDW in PregnancyHigher RDW levels (>14.5%) have been associated with higher risks of preeclampsia, gestational diabetes, and cholestasis. A sudden rise in RDW and mean platelet volume (MPV) is a biomarker for preterm labor risk. A sudden rise in RDW is a biomarker for intrahepatic cholestasis of pregnancy (ICP). Most Common Causes of High RDW in Pregnancy
Low RDW in PregnancyWhen the RDW is low, this indicates a decrease in the variability of the red blood cell sizes: a lower percentage are not shaped the same. There is a normal amount of variation in red blood cell size, as younger blood cells are slightly larger. But when the percentage is too low, this can indicate that there is not enough new RBC production. Most Common Causes of Low RDW in Pregnancy
Anything that decreases overall red blood cell production can cause a lower RDW by decreasing the release of young red blood cells. See RBC article. Ready to advance your practice with functional medicine?Transform your patient care with advanced lab analysis training. MEAC Credits Available Now. Copyright © 2024 Functional Maternity, all rights reserved. Medical Disclaimer: This content is for educational purposes only and is intended for licensed medical professionals. It is based on current research, subject to change, and not intended to diagnose, treat, or prevent any medical condition. This information does not replace consultation with a qualified healthcare provider. Seek professional medical evaluation and treatment from a licensed provider. Use of this information is at your own risk.
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Hi There!I'm Sarah Thompson, the author of Functional Maternity, and the upcoming book Beyond Results - A practitioner's Handbook to Effective Functional Lab Analysis in Pregnancy. Lab Tests
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