Mean Corpuscular Hemoglobin Concentration (MCHC)

Some researchers argue that the Mean Corpuscular Hemoglobin Concentration (MCHC) is more accurate in assessing actual functional hemoglobin levels, as it adjusts for the red blood cell production rate and loose hemoglobin. This means that it is less likely to account for free hemoglobin in the blood that may be present due to hemolysis or cell death. Yet, this RBC indices is rarely used in obstetrical care, and the standard hemoglobin and hematocrit are more commonly used.

MCHC Testing

Mean corpuscular hemoglobin concentration (MCHC) measures the concentration of hemoglobin in a red blood cell relative to the size of the cell itself.

​It tells you what percentage of the blood cell is composed of hemoglobin.

MCHC in Pregnancy

MCHC levels increase slightly throughout pregnancy, reaching a peak between 30 and 34 weeks. This is explained by an increase in overall production and release into circulation of immature red blood cells, which are larger in size and contain more hemoglobin than older RBCs. This change should coincide with slight  mean corpuscular volume (MCV) and MCH increases.

High MCHC in Pregnancy

There is limited data on the application of this indice in pregnancy.

Most Common Causes of High MCHC in Pregnancy

• Nutritional Deficiencies (Copper, Vitamin B12 (Cobalamin), Vitamin B9 (Folate)
• Hyperthyroidism
• Hemolytic Anemia
• Hypoxia/Sleep Apnea
• Certain Medications (Diuretics)
• Iron Overload/Hemochromatosis
• Myeloproliferative Diseases (Polycythemia) 

Low MCHC in Pregnancy

There is limited data on the application of this indice in pregnancy.

Most Common Causes of Low MCHC in Pregnancy

• Iron Deficiency (with or without Anemia)
• Vitamin B6 (Pyridoxine) Deficiency
• Heavy Metal Exposure
• Thalassemia
• Sideroblastic Anemia
• Gut Pathogens/Parasites
• Selenium Deficiency

Want to Know More...

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Medical Disclaimer:
This content is for educational purposes only and is intended for licensed medical professionals. It is based on current research, subject to change, and not intended to diagnose, treat, or prevent any medical condition. This information does not replace consultation with a qualified healthcare provider. Seek professional medical evaluation and treatment from a licensed provider. Use of this information is at your own risk.

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